Clinical Diagnostic Testing for Human Cytomegalovirus Infections. (5th March 2020)

• Record Type: Journal Article
• Authors: Razonable, Raymund R; Inoue, Naoki; Pinninti, Swetha G; Boppana, Suresh B; Lazzarotto, Tiziana; Gabrielli, Liliana; Simonazzi, Giuliana; Pellett, Philip E; Schmid, D Scott
• Is Part Of: Journal of infectious diseases. Volume 221(2020)Supplement 1
• Page Start: S74
• Page End: S85
• Publication Date: 2020-03-05
• Subjects: human cytomegalovirus -- pregnancy -- congenital infection -- diagnosis; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiz601
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more congenital infections worldwide than any other agent. Congenital HCMV (cCMV) infections are the leading nongenetic cause of sensorineural hearing loss and a source of significant neurological disabilities in children. While there is overlap in the clinical and laboratory approaches to diagnosis of HCMV infections in these settings, the management, follow-up, treatment, and diagnostic strategies differ considerably. As yet, no country has implemented a universal screening program for cCMV. Here, we summarize the issues, limitations, and application of diagnostic strategies for transplant recipients and congenital infection, including examples of screening programs for congenital HCMV that have been implemented at several centers in Japan, Italy, and the United States.