Weight Loss Improves HRQOL Physical Function and Vitality More in Blacks Than Whites. (16th December 2020)

• Record Type: Journal Article
• Authors: Boudreau, Robert; Venditti, Elizabeth; Danielson, Michelle; Glynn, Nancy; Jakicic, John; Newman, Anne; Albert, Steven
• Is Part Of: Innovation in aging. Volume 4(2020)Supplement 1
• Page Start: 840
• Page End: 840
• Publication Date: 2020-12-16
• Subjects: Aging -- Periodicals; Gerontology -- Periodicals; 612.67
• DOI: 10.1093/geroni/igaa057.3079
• Languages: English
• ISSNs: 2399-5300

Abstract

Abstract: Participant-reported outcomes are important. Prior MOVE UP reports show ≥5% weight loss was not significantly associated with depressive symptoms but was associated with positive SPPB physical function and the Physical Component Score of the SF-36 HRQOL scale. We examined the SF-36 subscales that showed, a priori, clinically meaningful +5.0-point increases over 13 months, the change in subscales per 5% weight loss, and variability by race. Among all participants (n =240) several subscales show significant pre-post changes [mean (SD)] but only Vitality [+5.6 (15.4)] and Physical Function [+5.0 (16.7)] meet the criterion. Blacks (n = 60) compared to Whites (n = 172) had higher baseline scores on these subscales, were less likely to lose ≥5% (31.7% vs. 59.9%), but mixed regression models indicate that those who did demonstrated a larger change on Vitality (+5.2; p<0.048) than Whites (+3.1; p<0.0003). Studying weight loss and HRQOL associations in larger minority samples is needed.