Combined application of MRS and DWI can effectively predict cell proliferation and assess the grade of glioma: A prospective study. (January 2021)

• Record Type: Journal Article
• Authors: Hu, Xvlei; Xue, Meifeng; Sun, Shengyu; Zou, Yourui; Li, Jiangping; Wang, Xiaodong; Liu, Xiaoli; Ma, Hui
• Is Part Of: Journal of clinical neuroscience. Volume 83(2021)
• Page Start: 56
• Page End: 63
• Publication Date: 2021-01
• Subjects: LGG low-grade glioma -- HGG high-grade glioma -- Cho choline -- Cr creatine -- NAA N-acetylaspartate -- ADC apparent diffusion coefficient -- ADCT tumor parenchyma ADC -- ADCH contralateral mirror brain tissue ADC -- rADC relative apparent diffusion coefficient -- PRE Predicted probability -- AUC area under the curve -- ROC receiver operating characteristic curve -- IDH isocitrate dehydrogenase; Glioma -- Magnetic resonance spectroscopy -- Diffusion weighted imaging -- Diagnosis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.11.030
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: MRS and DWI can effectively predict cell proliferation before operation. DWI can make up for the shortcomings of MRS. MRS combined with DWI can further improve sensitivity and specificity in predicting the grade of Glioma. Fisher's linear discriminant functions is an ideal predictive LDA model for diagnosing and differentiating LGG from HGG. Abstract: In order to assess combined application of MRS and DWI for prediction cell proliferation and grade diagnosis of glioma, We prospectively collected the Cho/Cr, Cho/NAA, Cr/NAA of MRS and tumor parenchyma ADC (ADCT ), contralateral mirror brain tissue ADC (ADCH ), rADC (rADC = ADCT /ADCH ). According to postoperative pathology, the patients were divided into two groups: LGG group and HGG group, compared differences of age, gender, Ki67, MRS, DWI between two groups. Next, we analyzed the correlation between MRS, DWI and Ki67. On this basis, the sensitivity and specificity of MRS, DWI and MRS combined with DWI (MRS + DWI) in diagnosis of glioma grade were evaluated. The differences of Ki67, Cho/Cr, Cho/NAA, Cr/NAA, ADCT, rADC between LGG group and HGG group were statistically significant (p = 0.000, 0.000, 0.000, 0.008, 0.000, and 0.000 respectively). From ROC curve, area under the curve (AUC), sensitivity and specificity of Cho/Cr, Cho/NAA, Cr/NAA, ADCT, rADC, PRE (MRS + DWI) were (0.901, 86.7%, 85.7%), (0.876, 80.0%, 82.1%), (0.704, 63.3%, 71.4%), (0.862, 82.1%, 83.3%), (0.820, 75.0%, 76.7%), (0.920, 86.7%, 89.3%), respectively. Fisher's linear discriminant functions results suggest: Y1 = -20.447 + 3.46X1 + 17.141X2 (LGG), Y2 = -19.415 + 4.828X1 + 14.543X2 (HGG). Our study suggested that MRS and DWI can effectively predict cell proliferation preoperative. MRS combined with DWI can further improve sensitivity and specificity in assessing the grade of glioma.