Changes Depression- and Anxiety- like Behaviors following Selective Breeding for Cocaine Reinforcement. (January 2021)

• Record Type: Journal Article
• Authors: Grasing, Michael J; Xu, Haiyang; Idowu, Jessica Y; Grasing, Kenneth
• Is Part Of: Psychiatry research. Volume 295(2021)
• Publication Date: 2021-01
• Subjects: Forced swimming test -- Self-Administration -- and Stress-Induced Immobility; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2020.113637
• Languages: English
• ISSNs: 0165-1781

Abstract

Highlights: Disorders of mood and anxiety play an important role in substance use Common changes in genotype may underlie both types of behavior In a genetic strain with increased drug-taking, immobility varied with strain and sex Anxiety-like behavior was increased in the line selected for greater cocaine taking This trait may lead to an enhanced motivation for cocaine self-administration Abstract: The LS and HS are rat lines selectively bred for altered cocaine self-administration. Given the importance of mental health in substance use, these lines were evaluated for putative depression- and anxiety- like behaviors through forced swimming and exploration of a plus maze. We found increases of struggling in LS males, climbing in LS females, and swimming in HS males; with biphasic effects on immobility in the HS strain. HS rats had fewer entries into and less time spent in open arms of the plus maze, consistent with greater anxiety-like behavior, which may contribute to enhanced drug taking. Graphical Abstract: Image, graphical abstract