Twisting gating residues in the Orai pore. (January 2021)

• Record Type: Journal Article
• Authors: Bonhenry, Daniel; Schober, Romana; Schindl, Rainer
• Is Part Of: Cell calcium. Volume 93(2021)
• Publication Date: 2021-01
• Subjects: STIM1 -- Orai1 -- Pore -- Gating -- Ca2+ channel; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102323
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Abstract: The store-operated calcium channels Orai1−3 form extraordinary long and funnel like pores, in stark contrast to a classical pore loop architecture. A hydrophobic segment centrally located in the Orai pore controls gating. Here, we comment on a recent work that describes decisive binding between three residues that controls the open and closed conformation of Orai channels.