Heavy Elements Revealed in Jejunum of Simian Immunodeficiency Virus Infected Monkeys by Microparticle Induced X‐Ray Emission. Issue 1 (15th May 2020)

• Record Type: Journal Article
• Authors: Whitlow, Harry J.; Deoli, Naresh T.; de Vera, Armin; Morgan, Karen; Villinger, Francois
• Other Names: Kuznetsov Andrej guestEditor.; Dangtip Somsak guestEditor.; Intarasiri Saweat guestEditor.
• Is Part Of: Physica status solidi. Volume 218:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-15
• Subjects: human immunodeficiency virus -- MeV ion microprobes -- particle-induced X-ray emission -- simian immunodeficiency virus; Solid state physics -- Periodicals; Solids -- Industrial applications -- Periodicals; 530.41
• DOI: 10.1002/pssa.202000107
• Languages: English
• ISSNs: 1862-6300

Abstract

Abstract : Archived jejunum tissue block specimens from control and simian immunodeficiency virus‐infected rhesus macaques are characterized using particle‐induced X‐ray emission (PIXE) in a MeV ion microprobe with 2 MeV protons. The results show considerable variance in the concentration of some elements (Ti, Mn, and Fe) between viremic and control tissue. Ti, Mn, and Fe are present at levels 50‐fold lower in samples from viremic versus control monkeys, a difference markedly higher than previously reported for infections. Pb and Ti are observed particularly in the crypts of both viremic and control jejunum samples. This is likely to be caused by ingestion of paint fragments picked from the cages used to house the animals. Abstract : Microparticle induced X‐ray emission (μ‐PIXE) is used to study heavy elements in the jejunum of monkeys infected with simian immunodeficiency virus (SIV). The results show differences in concentration exceeding a factor 10. Concentration hotspots that may be associated with ingestion or diet are found for many elements including Pb that could explain the variability.