A combination of circulating chemokines as biomarkers of obesity‐induced insulin resistance at puberty. Issue 2 (27th August 2020)

• Record Type: Journal Article
• Authors: Rivera, Patricia; Martos‐Moreno, Gabriel Á.; Barrios, Vicente; Suárez, Juan; Pavón, Francisco J.; Chowen, Julie A.; Rodríguez de Fonseca, Fernando; Argente, Jesús
• Is Part Of: Pediatric obesity. Volume 16:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-27
• Subjects: adolescence -- biomarkers -- cytokine -- insulin resistance -- obesity -- puberty; Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/ijpo.12711
• Languages: English
• ISSNs: 1747-7174

Abstract

Summary: Background: In obesity adipose tissue undergoes structural re‐modelling leading to a chronic low‐grade inflammatory state linked to insulin resistance (IR). Objective: We aimed to develop a clinically relevant biomarker model for stratifying IR in adolescents with obesity. Methods: Cytokines [tumour cell derived factor 1α, monocyte chemoattract protein (MCP) 1, eotaxin and fractalkine], growth factors [brain‐derived neurotrophic factor, pro‐fibrotic platelet‐derived growth factor (PDGF‐BB) and insulin‐like growth factor 1] and biochemical/metabolic factors were analysed in serum of 143 pubertal patients with obesity (50% IR; 50% non‐IR) and 33 controls. Factor analysis, correlation, binary logistic regression and receiver operating characteristic analysis were used to evaluate combinations of these biomarkers as possible diagnostic tools for IR. Results: Two biomarker IR models combining levels of triglycerides (TG)/HDL, eotaxin, MCP‐1 and PDGF‐BB in pubertal patients with obesity of both sexes were defined. Altered levels of MCP‐1, eotaxin, and PDGF‐BB constitute a main component that determines 27.7% of the variance explaining IR. Growth and inflammatory factors comprise two other components linked to the first, together accounting for 59.2% of the variance determining IR. Conclusions: PDGF‐BB, MCP‐1, eotaxin, TG and cholesterol concentrations constitute a solid panel of biomarkers associated with IR in pubertal children with obesity that could be useful in their stratification in a clinical setting for stratification.