Detection of disability worsening in relapsing‐remitting multiple sclerosis patients: a real‐world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register. (6th November 2020)

• Record Type: Journal Article
• Authors: Lepore, V.; Bosetti, C.; Santucci, C.; Iaffaldano, P.; Trojano, M.; Mosconi, P.
• Other Names: Totaro Rocco investigator.; Coniglio Maria Gabriella investigator.; Bossio Roberto Bruno investigator.; Valentino Paola investigator.; Gatto Maurizia investigator.; Paolicelli Damiano investigator.; Ardito Bonaventura investigator.; Barcella Valeria investigator.; Capone Lorenzo investigator.; Nicolao Piero investigator.; Lugaresi Alessandra investigator.; Rini Augusto investigator.; Bianchi Marta investigator.; Plasmati Imma investigator.; Cocco Eleonora investigator.; Docimo Renato investigator.; De Luca Giovanna investigator.; Mondino Fiorella investigator.; Di Sapio Alessia investigator.; Clerici Raffaella investigator.; Mascoli Nerina investigator.; Ferrò Maria Teresa investigator.; Chisari Clara Grazia investigator.; Maimone Davide investigator.; Strumia Silvia investigator.; Pugliatti Maura investigator.; Cargnelutti Daniela investigator.; Caniatti Luisa Maria investigator.; Avolio Carlo investigator.; Crociani Paola investigator.; Amato Maria Pia investigator.; Massacesi Luca investigator.; Malagù Susanna investigator.; Ribizzi Giuseppe investigator.; Inglese Matilde investigator.; Venturi Simonetta investigator.; Gazzola Paola investigator.; Pizio Nicola Renato investigator.; Brichetto Giampaolo investigator.; Plewnia Katrin investigator.; Bellantonio Paolo investigator.; Balgera Roberto investigator.; De Robertis Francesca investigator.; Fermi Silvia investigator.; Fausto Franco investigator.; Mazzoni Monica investigator.; Meucci Giuseppe investigator.; Cartechini Elisabetta investigator.; Cavaletti Guido investigator.; Buccafusca Maria investigator.; Bramanti Placido investigator.; Romeo Marzia investigator.; Rovaris Marco investigator.; Ronzoni Marco investigator.; Confalonieri Paolo investigator.; Chiveri Luca investigator.; Bertora Pierluigi investigator.; Tonietti Simone investigator.; De Riz Milena investigator.; Protti Alessandra investigator.; Sola Patrizia investigator.; Maremmani Carlo investigator.; Lus Giacomo investigator.; Gallo Antonio investigator.; Maniscalco Giorgia Teresa investigator.; Morra Vincenzo Brescia investigator.; Cacchio Gabriella investigator.; Iodice Rosa investigator.; Ragno Michele investigator.; Sinisi Leonardo investigator.; Cantello Roberto investigator.; Piras Maria Luisa investigator.; Salemi Giuseppe investigator.; Cottone Salvatore investigator.; Grimaldi Luigi M. E. investigator.; Corea Francesco investigator.; Santangelo Giuseppe investigator.; Immovili Paolo investigator.; Gallo Paolo investigator.; D'Andrea Francesco investigator.; Frittelli Cristina investigator.; Pasquali Livia investigator.; Falcini Mario investigator.; Granella Franco investigator.; Pesci Ilaria investigator.; Ancona Anna Luisa investigator.; Bergamaschi Roberto investigator.; Giordano Antonello investigator.; Di Napoli Mario investigator.; Romano Silvia investigator.; Pozzilli Carlo investigator.; Mirabella Massimiliano investigator.; Conte Antonella investigator.; Galgani Simonetta investigator.; Peresson Marco investigator.; Grasso Maria Grazia investigator.; Ferraro Elisabetta investigator.; Capone Fioravante investigator.; Marfia Girolama Alessandra investigator.; de Pascalis Daniela investigator.; Piantadosi Carlo investigator.; Valeriani Massimiliano investigator.; Busillo Vincenzo investigator.; Barone Paolo investigator.; De Stefano Nicola investigator.; Ulivelli Monica investigator.; Santuccio Giuseppe investigator.; Parodi Sergio investigator.; Bucello Sebastiano investigator.; Traccis Sebastiano investigator.; Zarbo Roberto investigator.; Tassinari Tiziana investigator.; Bandini Fabio investigator.; Cavalla Paola investigator.; Clerico Marinella investigator.; De Rosa Giulia investigator.; Bertolotto Antonio investigator.; Imperiale Daniele investigator.; Sarchielli Paola investigator.; Celani Maria Grazia investigator.; Vianello Marika investigator.; Marini Bruno investigator.; Fortunato Marianna investigator.; Zaffaroni Mauro investigator.; Nasuelli Davide investigator.; Banfi Paola investigator.; Brioschi Andrea Mauro investigator.; Solaro Claudio investigator.; Quatrale Rocco investigator.; Rossi Patrizia investigator.; Gajofatto Alberto investigator.; Trojano Maria investigator.; Battaglia Mario Alberto investigator.; Capobianco Marco investigator.; Pugliatti Maura investigator.; Ulivelli Monica investigator.; Mosconi Paola investigator.; Patti Francesco investigator.; Amato Maria Pia investigator.; Bergamaschi Roberto investigator.; Comi Giancarlo investigator.;
• Is Part Of: European journal of neurology. Volume 28:Number 2(2021)
• Page Start: 567
• Page End: 578
• Publication Date: 2020-11-06
• Subjects: disability -- Expanded Disability Status Scale -- multiple sclerosis -- register -- relapse‐remitting -- worsening; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.14589
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: In relapsing‐remitting multiple sclerosis patients (RRMS) disability progressively accumulates over time. To compare the cumulative probability of 6‐month confirmed disability‐worsening events using a fixed baseline or a roving Expanded Disability Status Scale (EDSS) reference, in a real‐world setting. Methods: A cohort of 7964 RRMS patients followed for 2 or more years, with EDSS scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register. The overall probability of confirmed disability‐worsening events and of confirmed disability‐worsening events unrelated to relapse was evaluated using as reference a fixed baseline EDSS score or a roving EDSS score in which the increase had to be separated from the last EDSS assessment by at least 6 or 12 months. Results: Using a fixed baseline EDSS reference, the cumulative probability of 6‐year overall confirmed disability‐worsening events was 33.2%, and that of events unrelated to relapse was 10.9% (33% of overall confirmed disability‐worsening events). Using a roving EDSS, the proportions were respectively 35.2% and 21.3% (61% of overall confirmed disability‐worsening events). Conclusions: In a real‐world setting, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability‐worsening events unrelated to relapse in RRMS patients. Abstract : A cohort of 7964 relapsing‐remitting multiple sclerosis patients (RRMS) followed for 2 or more years, with Expanded Disability Status Scale (EDSS) scores recorded every 6 months, was selected from the Italian Multiple Sclerosis Register to compare the cumulative probability of 6‐month confirmed disability‐worsening events using a fixed baseline or a roving EDSS reference. Using a roving EDSS reference method, the 6‐ and 10‐year cumulative probabilities of worsening events unrelated to relapses almost doubled. In this real‐world setting, in RRMS patients, roving EDSS reference scores appear to be more sensitive for detecting confirmed disability‐worsening events unrelated to relapse.