Liquid‐Flowing Graphene Chip‐Based High‐Resolution Electron Microscopy. Issue 2 (20th November 2020)

• Record Type: Journal Article
• Authors: Koo, Kunmo; Park, Jungjae; Ji, Sanghyeon; Toleukhanova, Saltanat; Yuk, Jong Min
• Is Part Of: Advanced materials. Volume 33:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-20
• Subjects: atomic resolution imaging -- biological imaging platforms -- graphene liquid cells -- liquid‐phase transmission electron microscopy -- operando electron microscopy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202005468
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: The recent advances in liquid‐phase transmission electron microscopy represent tremendous potential in many different fields and exciting new opportunities. However, achieving both high‐resolution imaging and operando capabilities remain a significant challenge. This work suggests a novel in situ imaging platform of liquid‐flowing graphene chip TEM (LFGC‐TEM) equipped with graphene viewing windows and a liquid exchange system. The LFGCs are robust under high‐pressure gradients and rapid liquid circulation in ranges covering the experimental conditions accessible with conventional thick SiN x chips. LFGC‐TEM provides atomic resolution for colloidal nanoparticles and molecular‐level information limits for unstained wet biomolecules and cells that are comparable to the resolutions achievable with solid‐phase and cryogenic TEM, respectively. This imaging platform can provide an opportunity for live imaging of biological phenomena that is not yet achieved using any current methods. Abstract : The liquid‐flowing graphene chip (LFGC) is a novel imaging platform enabling the atomic‐scale observation of liquid‐phase reactions during in operando circumstances. Graphene viewing windows and anti‐bulging SiN x supports provide a controllable liquid thickness and structural integrity under harsh experimental conditions. Using LFGC, both atomic‐resolution imaging and molecular‐level information for inorganic and biological samples can be acquired under liquid circulation.