Versatile Types of Cyclodextrin‐Based Nucleic Acid Delivery Systems. Issue 1 (16th September 2020)

• Record Type: Journal Article
• Authors: Xu, Chen; Yu, Bingran; Qi, Yu; Zhao, Nana; Xu, Fu‐Jian
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-16
• Subjects: cyclodextrin -- gene therapy -- nucleic acid delivery -- organic/inorganic nanohybrid -- supramolecular self‐assembly; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202001183
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Nowadays, nucleic acid therapy has become a promising way for the treatment of various malignant diseases. Cyclodextrin (CD)‐based nucleic acid delivery systems have attracted widespread attention due to the favorable chemical structures and excellent biological properties of CD. Recently, a variety of CD‐based nucleic acid delivery systems has been designed according to the different functions of CD for flexible gene therapies. In this review, the construction strategies and biomedical applications of CD‐based nucleic acid delivery systems are mainly focused on. The review begins with an introduction to the synthesis and properties of simple CD‐grafted polycations. Thereafter, CD‐related supramolecular assemblies based on different guest components are discussed in detail. Finally, different CD‐based organic/inorganic nanohybrids and their relevant functions are demonstrated. It is hoped that this brief review will motivate the delicate design of CD‐based nucleic acid delivery systems for potential clinical applications. Abstract : Various cyclodextrin (CD)‐based nucleic acid delivery systems including CD‐grafted polycations, supramolecular self‐assembly systems, and organic/inorganic nanohybrids can be readily prepared for multiple gene therapies of different diseases.