Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study. Issue 1 (7th August 2020)

• Record Type: Journal Article
• Authors: Allison, Derek B.; Smith, Alexander P.; An, Daniel; Miller, James Adam; Shafique, Khurram; Song, Sharon; Viswanathan, Kartik; Eykman, Elizabeth; Rao, Rema A.; Wiles, Austin; Barkan, Güliz A.; Nayar, Ritu; Fadda, Guido; Powers, Celeste N.; Rossi, Esther Diana; Siddiqui, Momin T.; Ali, Syed Z.; Kholová, Ivana; Layfield, Lester J.; Field, Andrew; Baloch, Zubair; Maleki, Zahra
• Is Part Of: Cancer cytopathology. Volume 129:Issue 1(2021)
• Page Start: 43
• Page End: 52
• Publication Date: 2020-08-07
• Subjects: cytology -- cytopathology -- fine‐needle aspiration (FNA) -- head and neck pathology -- Milan System for Reporting Salivary Gland Cytopathology -- pleomorphic adenoma -- salivary gland -- Warthin tumor; Cancer -- Cytopathology -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Technique -- Periodicals; 611.01815
• DOI: 10.1002/cncy.22339
• Languages: English
• ISSNs: 1934-662X

Abstract

Abstract : Background: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has established distinct diagnostic categories for reporting cytopathological findings, and each is associated with a defined risk of malignancy (ROM). However, the ROM is applied at the overall category level and is not specific for particular morphological entities within a category. Here, the diagnostic performance of the MSRSGC for pleomorphic adenoma (PA) and Warthin tumor (WT) is reported. Methods: The pathology archives of 11 institutions from 4 countries were retrospectively searched to identify all salivary gland fine‐needle aspiration (FNA) biopsies with a differential or definitive diagnosis of PA or WT and all resection specimens with a diagnosis of PA or WT; only paired cases were included. All FNA diagnoses were retrospectively classified according to the MSRSGC. Results: A total of 1250 cases met the inclusion criteria, and they included 898 PA cases and 352 WT cases. The ROM in the benign neoplasm category was 3.0% and 1.3% for cases with a differential or definitive diagnosis of PA and WT, respectively. The ROM in the salivary gland neoplasm with uncertain malignant potential (SUMP) category was 2.7% and 18.8% for PA and WT, respectively ( P = .0277). The diagnostic accuracy for PA and WT was 95.1% and 96.1%, respectively. Conclusions: The diagnostic accuracy for PA and WT on FNA is high. Furthermore, these findings highlight the difference in the ROMs associated with 2 specific differential diagnoses in the SUMP category: basaloid neoplasms and oncocytoid neoplasms. Abstract : The diagnostic accuracy for pleomorphic adenoma and Warthin tumor is 95.1% and 96.1%, respectively, in a large, international, multi‐institutional cohort. The risk of malignancy in the benign neoplasm category of the Milan system is 3.0% and 1.3% for cases with a differential or definitive diagnosis of pleomorphic adenoma and Warthin tumor, respectively.