Synthesis of Seleno Oxindoles via Electrochemical Cyclization of N‐arylacrylamides with Diorganyl Diselenides. Issue 1 (18th November 2020)

• Record Type: Journal Article
• Authors: Wang, Xin‐Yu; Zhong, Yuan‐Fang; Mo, Zu‐Yu; Wu, Shi‐Hong; Xu, Yan‐Li; Tang, Hai‐Tao; Pan, Ying‐Ming
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 1(2021)
• Page Start: 208
• Page End: 214
• Publication Date: 2020-11-18
• Subjects: Electrochemical synthesis -- Cross-coupling reaction -- Oxindole skeletons; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202001192
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The tandem cyclization of acrylamide with diselenides facilitated by electrochemical oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C−Se bond. A series of seleno oxindoles with pharmacological activity were obtained by using this well‐designed tandem cyclization strategy. The in vitro antitumor activity of the compounds was also screened through MTT assay. Results showed that the seleno oxindoles exhibited better antitumor activity than other oxindole derivatives. Abstract :