Copper(II)‐Catalysed Aerobic Oxidative Coupling of Arylamines with Hexafluoroisopropanol: An Alternative Methodology for Constructing Fluorinated Compounds. Issue 1 (12th November 2020)

• Record Type: Journal Article
• Authors: Wu, Liangying; Song, Yang; Li, Zhanchong; Guo, Jiabao; Yao, Xiaoquan
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 1(2021)
• Page Start: 268
• Page End: 274
• Publication Date: 2020-11-12
• Subjects: Copper(II) catalysis -- Fluorination -- Aerobic oxidative coupling -- Arylamines; Hexafluoroisopropanol; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202001048
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The selective functionalisation of arylamine derivatives with hexafluoroisopropanol through copper(II)‐catalysed aerobic oxidative coupling was developed to generate various fluoroalkylated arylamines under mild conditions. This method has a wide substrate scope with excellent functional group tolerance and provides the fluorinated products in good to excellent yields. Furthermore, preliminary studies indicate that this reaction occur via a radical mechanism. This protocol, which uses atmospheric O2 as an oxidant, provides an alternative green route for constructing fluorinated compounds. Abstract :