PGC-1α Induction in Pulmonary Arterial Hypertension. (29th August 2012)

• Record Type: Journal Article
• Authors: Mata, Manuel; Sarrion, Irene; Milian, Lara; Juan, Gustavo; Ramon, Mercedes; Naufal, Dolores; Gil, Juan; Ridocci, F.; Fabregat-Andrés, O.; Cortijo, Julio
• Other Names: Mounier Remi Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2012(2012)
• Publication Date: 2012-08-29
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2012/236572
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Idiopathic Pulmonary arterial hypertension (IPAH) is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure (PAP) with subsequent right-sided heart failure and dead. Hypoxia induces the expression of peroxisome proliferator activated receptor γ coactivator-1 α (PGC-1 α ) which regulates oxidative metabolism and mitochondrial biogenesis. We have analysed the expression of PGC-1 α, cytochrome C (CYTC), superoxide dismutase (SOD), the total antioxidant status (TAS) and the activity of glutathione peroxidase (GPX) in blood samples of IPAH patients. Expression of PGC-1 α was detected in IPAH patients but not in healthy volunteers. The mRNA levels of SOD were lower in IPAH patients compared to controls (3.93 ± 0.89 fold change). TAS and GPX activity were lower too in patients compared to healthy donors, (0.13 ± 0.027 versus 0.484 ± 0.048 mM and 56.034 ± 10.37 versus 165.46 ± 11.38 nmol/min/mL, resp.). We found a negative correlation between expression levels of PGC-1 α and age, PAP and PVR, as well as a positive correlation with CI, PaO2, mRNA levels of CYTC and SOD, TAS and GPX activity. These results taken together are indicative of the possible role of PGC-1 α as a potential biomarker of the progression of IPAH.