Copper-catalyzed alkynylation/annulation cascades of N-allyl ynamides: regioselective access to medium-sized N-heterocycles. Issue 1 (9th October 2020)

• Record Type: Journal Article
• Authors: Yang, Xu-Heng; Huang, Jian; Wang, Fang; Liu, Zhuoliang; Li, Yujiao; Tao, Cheng-an; Wang, Jianfang
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 1(2021)
• Page Start: 18
• Page End: 24
• Publication Date: 2020-10-09
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo00837k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A synthetic strategy based on sequential application of aza-Claisen rearrangement, C–H functionalization, C–N coupling and cyclization as key steps has been developed for the synthesis of 6-, 7-, 8-, and 9-membered rings N -heterocycles. Abstract : A synthetic strategy based on sequential application of aza-Claisen rearrangement, C–H functionalization, C–N coupling and cyclization as key steps has been developed for the synthesis of various medium-sized N -heterocycles of pharmaceutical relevance. This efficient new method exhibits a broad scope and provides a highly efficient synthesis of N -heterocycles of different ring sizes (6-, 7-, 8-, and 9-membered rings) in moderate to good yields.