Synthesis, spectroscopic characterization and DNA/HSA binding studies of (phenyl/naphthyl)ethenyl-substituted 1, 3, 4-oxadiazolyl-1, 2, 4-oxadiazoles. (16th December 2020)

• Record Type: Journal Article
• Authors: Mayer, João C. P.; Acunha, Thiago V.; Rodrigues, Oscar E. D.; Back, Davi F.; Chaves, Otávio A.; Dornelles, Luciano; Iglesias, Bernardo A.
• Is Part Of: New journal of chemistry. Volume 45:Number 1(2021)
• Page Start: 471
• Page End: 484
• Publication Date: 2020-12-16
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj04530f
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Novel 1, 3, 4-oxadiazolyl-1, 2, 4-oxadiazole derivatives with promising photophysical and DNA/HSA-binding properties are reported. Abstract : Two new series of conjugated arylethenyl-1, 3, 4-oxadiazolyl-1, 2, 4-oxadiazoles were obtained and spectroscopically characterized in terms of UV-Vis absorption, fluorescence and interaction with CT-DNA and Human Serum Albumin (HSA) biomolecules. Phenyl- and 1-naphthyl-bearing examples were analysed, and the spectroscopic properties of its substitution series were compared, showing extensive conjugation in all compounds and absorption differences due to both the aryl–ethenyl subunit and substituted phenyl/phenylene at the 1, 2, 4-oxadiazole side. Strong binding interactions of the obtained compounds with CT-DNA and moderate HSA-association capability were observed spectroscopically, and further docking studies were performed.