A multi-photon fluorescent probe based on quinoline groups for the highly selective and sensitive detection of lipid droplets. Issue 24 (8th October 2020)

• Record Type: Journal Article
• Authors: Zhang, Sijing; Yang, Zhenghui; Li, Minghao; zhang, Qiong; Tian, Xiaohe; Li, Dandan; Li, Shengli; Wu, Jieying; Tian, Yupeng
• Is Part Of: Analyst. Volume 145:Issue 24(2020)
• Page Start: 7941
• Page End: 7945
• Publication Date: 2020-10-08
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d0an01847c
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Compound L3 possesses excellent two/three photon absorption properties, and has been successfully applied in the bioimaging of LDs. Abstract : Compared to general fluorescent probes, multi-photon fluorescent probes exhibit deeper tissue penetration, lower auto-fluorescence and lower photo-toxicity in the bio-imaging field. Herein, we synthesized a series multi-photon fluorescent probe (L1–L3 ) based on quinolone groups. Of notably, the three-photon fluorescence of L3 significantly enhanced when L3 interacted with liposome; moreover, L3 exhibited high selectivity towards lipid droplets in living cells. Due to its large Stokes shift, high selectivity and photon-stability, L3 was successfully used in lipid droplet imaging via multi-photon fluorescence bio-imaging.