High Force Unimanual Handgrip Contractions Increase Ipsilateral Sensorimotor Activation and Functional Connectivity. (1st January 2021)

• Record Type: Journal Article
• Authors: Andrushko, Justin W.; Gould, Layla A.; Renshaw, Doug W.; Ekstrand, Chelsea; Hortobágyi, Tibor; Borowsky, Ron; Farthing, Jonathan P.
• Is Part Of: Neuroscience. Volume 452(2021)
• Page Start: 111
• Page End: 125
• Publication Date: 2021-01-01
• Subjects: unimanual handgrip -- fMRI -- ipsilateral activation -- sensorimotor network -- functional connectivity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2020.10.031
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: High force unimanual handgrip contractions result in ipsilateral motor cortex activation. Sensorimotor network functional connectivity increases between hemispheres with high force unimanual handgrip contractions. Contralateral motor cortex activation does not appear to scale with increases in handgrip force. Abstract: Imaging and brain stimulation studies seem to correct the classical understanding of how brain networks, rather than contralateral focal areas, control the generation of unimanual voluntary force. However, the scaling and hemispheric-specificity of network activation remain less understood. Using fMRI, we examined the effects of parametrically increasing right-handgrip force on activation and functional connectivity among the sensorimotor network bilaterally with 25%, 50%, and 75% maximal voluntary contractions (MVC). High force (75% MVC) unimanual handgrip contractions resulted in greater ipsilateral motor activation and functional connectivity with the contralateral hemisphere compared to a low force 25% MVC condition. The ipsilateral motor cortex activation and network strength correlated with relative handgrip force (% MVC). Increases in unimanual handgrip force resulted in greater ipsilateral sensorimotor activation and greater functional connectivity between hemispheres within the sensorimotor network.