Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients. Issue 6 (November 2020)

• Record Type: Journal Article
• Authors: Kumar, Abhishek; Kumar, Piyush; Dungdung, Ajit; Kumar Gupta, Anitesh; Anurag, Aditya; Kumar, Abhinav
• Is Part Of: Diabetes & metabolic syndrome. Volume 14:Issue 6(2020)
• Page Start: 1951
• Page End: 1954
• Publication Date: 2020-11
• Subjects: COVID-19 -- SARS-CoV-2 -- Liver dysfunction -- Clinical profile; ALT Alanine transaminase -- AST Aspartate transaminase -- ALP Alkaline phosphatase -- ULN Upper limit of normal -- COVID-19 Coronavirus disease-19 -- SARS-CoV-2 Severe acute respiratory syndrome-coronavirus-2 -- IQR interquartile range; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2020.10.001
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background: – COVID-19 caused by SARS-CoV-2 leads to myriad range of organ involvement including liver dysfunction. Aim: To analyse the liver function in patients with COVID-19 and their association with respect to age, sex, severity of disease and clinical features. Materials and methods: This study was a cross-sectional study done at Rajendra Institute of Medical Sciences, Ranchi. 91 patients admitted with confirmed SARS-CoV-2 infection were included in this study and divided into asymptomatic, mild, moderate and severe groups. Liver function tests were compared among different severity groups. Results: Of 91 patients with COVID-19, 70 (76.9%) had abnormal liver function. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin levels was 1–2 × ULN in 33(36.3%), 34(37.3%), 12(13.2%), 6(6.6%) cases and >2 × ULN in 20(22%), 18(19.8%), 7(7.7%) and 2 (2.2%) cases respectively. Mean AST and ALP levels among different severity groups of COVID-19 was statistically significant (p < 0.05) whereas mean ALT and total bilirubin levels was statistically non-significant (p > 0.05). There was no statistical difference between males and females with regard to abnormal liver function. Liver injury was seen in 64.3% cases of hypertension and 73.3% cases of diabetes. Fever, myalgia, headache and breathlessness were found to be correlated significantly with severity of disease. Conclusion: Liver injury is common in SARS-CoV-2 infection and is more prevalent in the severe disease group. Aspartate transaminase and alkaline phosphatase are better indicators of covid-19 induced liver injury than alanine transaminase and total bilirubin. Highlights: Liver injury was seen in 76.9% cases of COVID-19 and in 64.3% cases of hypertension and 73.3% cases of diabetes. Mean AST & ALP among various severity groups of COVID-19 was statistically significant (p < 0.05). Mean ALT & total bilirubin values among these groups was statistically non-significant (p > 0.05).