ADVANCE system testing: Can coverage of pertussis vaccination be estimated in European countries using electronic healthcare databases: An example. (22nd December 2020)

• Record Type: Journal Article
• Authors: Emborg, Hanne-Dorthe; Kahlert, Johnny; Braeye, Toon; Bauwens, Jorgen; Bollaerts, Kaatje; Danieli, Giorgia; Duarte-Salles, Talita; Glismann, Steffen; Huerta-Alvarez, Consuelo; de Lusignan, Simon; Martín-Merino, Elisa; McGee, Chris; Correa, Ana; Tramontan, Lara; Weibel, Daniel; Sturkenboom, Miriam
• Is Part Of: Vaccine. Volume 38(2020)Supplement 2
• Page Start: B22
• Page End: B30
• Publication Date: 2020-12-22
• Subjects: Acellular pertussis vaccination -- Whole cell pertussis vaccination -- Vaccination coverage estimation -- Proof-of-concept study -- Database characteristics -- Benchmarking; ADVANCE Accelerated Development of VAccine beNefit-risk Collaboration in Europe -- aP acellular pertussis -- ATC Anatomical Therapeutic Chemical Classification System -- AUH Aarhus University Hospital Denmark -- BIFAP Database for Pharmacoepidemiological Research in Primary Care Spain -- B/R benefit-risk -- CumInc cumulative incidence -- DTP diphtheria tetanus pertussis -- DT diphtheria tetanus -- DTaP diphtheria tetanus acellular pertussis -- ECDC European Centre for Disease Prevention and Control -- PEDIANET Family Paediatrician Database Veneto vaccine registry Italy -- POC Proof of Concept -- PPFU Period Prevalence -- RCGP RSC Royal College of General Practitioners Research and Surveillance Centre UK -- SIDIAP Information System for Primary Care Research Spain -- SSI Statens Serum Institut Denmark -- THIN The Health Improvement Network UK -- wP whole cell pertussis; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2019.07.039
• Languages: English
• ISSNs: 0264-410X

Abstract

Highlights: Feasibility of estimating pertussis vaccination covering using 7 European healthcare databases. The majority of children were vaccinated at the recommended age of vaccination. Two estimation methods provided comparable coverage estimates. Benchmarking using national coverage estimates showed comparable results. The approached used provided reliable estimates for pertussis vaccination coverage. Abstract: Introduction: The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid benefit-risk (B/R) monitoring of vaccines, using existing healthcare databases in Europe. The objective of this paper was to assess the feasibility of using electronic healthcare databases to estimate dose-specific acellular pertussis (aP) and whole cell pertussis (wP) vaccine coverage. Methods: Seven electronic healthcare databases in four European countries (Denmark (n = 2), UK (n = 2), Spain (n = 2) and Italy (n = 1)) participated in this study. Children were included from birth and followed up to age six years. Vaccination exposure was obtained from the databases and classified by type (aP or wP), and dose 1, 2 or 3. Coverage was estimated using period prevalence. For the 2006 birth cohort, two estimation methods for pertussis vaccine coverage, period prevalence and cumulative incidence were compared for each database. Results: The majority of the 2, 575, 576 children included had been vaccinated at the country-specific recommended ages. Overall, the estimated dose 3 coverage was 88–97% in Denmark (birth cohorts from 2003 to 2014), 96–100% in the UK (2003–2014), 95–98% in Spain (2004–2014) and 94% in Italy (2006–2007). The estimated dose 3 coverage per birth cohort in Denmark and the UK differed by 1–6% compared with national estimates, with our estimates mostly higher. The estimated dose 3 coverage in Spain differed by 0–2% with no consistent over- or underestimation. In Italy, the estimates were 3% lower compared with the national estimates. Except for Italy, for which the two coverage estimation methods generated the same results, the estimated cumulative incidence coverages were consistently 1–10% lower than period prevalence estimates. Conclusion: This study showed that it was possible to provide consistent estimates of pertussis immunisation coverage from the electronic healthcare databases included, and that the estimates were comparable with the national estimates.