Mesoporous electroactive silver doped calcium borosilicates: Structural, antibacterial and myogenic potential relationship of improved bio-ceramics. Issue 3 (1st February 2021)

• Record Type: Journal Article
• Authors: Kumar, Alesh; Mittal, Ashwani; Das, Avik; Sen, Debasis; Mariappan, C.R.
• Is Part Of: Ceramics international. Volume 47:Issue 3(2021)
• Page Start: 3586
• Page End: 3596
• Publication Date: 2021-02-01
• Subjects: Mesoporous bio-ceramics -- Silver nanoparticle -- Sol-gel process -- Electrical property -- In-vitro bioactivity -- Antibacterial effect -- Myogenesis; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2020.09.207
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: In this work improved electroactive mesoporous Ag-doped bio-ceramics for medical usages are developed, examining their structural, electrical, in-vitro bioactivity, cell cultures and antibacterial properties against various classical pathogenic bacteria. Ag-containing mesoporous bio-ceramics (MBCs): xmol%Ag2 O - (100-x)[45.8CaO-8.4B2 O3 -45.8SiO2 ] where x = 2, 5, 7.5 and 10 were synthesized through a sol-gel method. The small angle X-ray scattering and electron microscopy studies reveal the embedment of silver nanoparticles in the samples. Existence of silver as Ag + /Ag 0 forms in the samples is confirmed by X-ray photoelectron spectroscopy. The N2 adsorption-desorption analysis evidence the mesoporous structure of the samples. The electrical conductivity of samples increases from 5.4 x 10 −8 S cm −1 for x = 2 to 1.9 x 10 −6 S cm −1 for x = 7.5 and then decreases to 0.9 x 10 −6 S cm −1 for x = 10 at 110 °C. In vitro bioactivity studies revealed that Ag-containing MBCs hold the bone-like hydroxyapatite formation after immersion in human blood plasma like-solution such as Dulbecco's Modified Eagle's Medium. The antibacterial effect of samples against pathogenic bacteria ( S. aureus, E. coli, P. monas aeruginosa, and B. cereus ) increases with Ag concentration (x = 7.5) and then decreases with Ag content (x = 10). Antibacterial effect is greater for the sample with high electrical conductivity. The cell culture studies evidence not considerable cytotoxic effects for Ag-containing MBCs. Finally, the C2C12 myoblast cell culture studies reveal the significant cell growths and differentiation (myogenesis) for high electrical conducting Ag-containing MBCs. Graphical abstract: Image 1