Current practice of pressurized intraperitoneal aerosol chemotherapy (PIPAC): Still standardized or on the verge of diversification?. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Sgarbura, Olivia; Villeneuve, Laurent; Alyami, Mohammad; Bakrin, Naoual; Torrent, Juan José; Eveno, Clarisse; Hübner, Martin; Abba, Julio; Afifi, Adnane; Mortensen, Michael Bau; Bharath, G.; Bhatt, Aditi; Yan So, Jimmy Bok; Brandl, Andreas; Ceelen, Wim; Cortes-Guiral, Delia; Courvoiser, Thomas; Coget, Julien; de Hingh, Ignace H.; Delhorme, Jean-Baptiste; Deo, Suryanarayana S.V.; di Giorgio, Andrea; Dumont, Frederic; Escayola, Cecilia; Ezanno, Anne-Cécile; Gagnière, Johan; Galindo, Julio; Glatz, Torben; Jäger, Tarkan; Jarra, Maximilian; Katdare, Ninad; Kepenekian, Vahan; Khomyakov, Vladimir M.; Kothonidis, Konstantinos; Laplace, Nathalie; Lavoue, Vincent; Lehmann, Kuno; Lynch, Craig; Mehta, Sanket; Moldovan, Bogdan; Nissan, Aviram; Nowacki, Maciej; Orry, David; Pérez, Gloria Ortega; Pabst, Urs G.; Paquette, Brice; Paskonis, Marius; Piso, Pompiliu; Pocard, Marc; Rau, Beate; Reymond, Marc; Ris, Frederic; Robella, Manuela; Silvestre-Rodriguez, José; Singh, Shivendra; Somashekhar, S.P.; Soravia, Claudio; Sourrouille, Isabelle; Taibi, Abelkader; Tempfer, Clemens; Torkington, Jared; Vizzielli, Giuseppe; Willaert, Wouter;
• Is Part Of: European journal of surgical oncology. Volume 47:Issue 1(2021)
• Page Start: 149
• Page End: 156
• Publication Date: 2021-01
• Subjects: ePIPAC -- Technique -- Treatment protocol -- Indications -- Safety -- Peritoneal metastasis -- PRGS; ePIPAC electrostatic Pressurized intraperitoneal aerosol chemotherapy -- HIPEC Hyperthermic intraperitoneal chemotherapy -- ISSPP International Society for the Study of Pleura and Peritoneum -- PIPAC Pressurized intraperitoneal aerosol chemotherapy -- PIPAC-CD PIPAC with cisplatin and doxorubicin -- PIPAC-OX PIPAC with oxaliplatin -- PM Peritoneal metastases -- PRGS Peritoneal regression grading score; Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2020.08.020
• Languages: English
• ISSNs: 0748-7983

Abstract

Abstract: Background: PIPAC is a new treatment modality for peritoneal cancer which has been practiced and evaluated until very recently by few academic centers in a highly standardized manner. Encouraging oncological outcomes and the safety profile have led to widespread adoption. The aim of this study was to assess current PIPAC practice in terms of technique, treatment and safety protocol, and indications. Methods: A standardized survey with 82 closed-ended questions was sent online to active PIPAC centers which were identified by help of PIPAC training centers and the regional distributors of the PIPAC-specific nebulizer. The survey inquired about center demographics (n = 8), technique (n = 34), treatment and safety protocol (n = 34), and indications (n = 6). Results: Overall, 62 out of 66 contacted PIPAC centers answered the survey (response rate 93%). 27 centers had performed >60 PIPAC procedures. A consensus higher than 70% was reached for 37 items (50%), and higher than 80% for 28 items (37.8%). The topics with the highest degree of consensus were safety and installation issues (93.5% and 80.65%) while chemotherapy and response evaluation were the least consensual topics (63.7 and 59.6%). The attitudes were not influenced by volume, PIPAC starting year, type of activity, or presence of peritoneal metastases program. Conclusion: Homogeneous treatment standards of new techniques are important to guarantee safe implementation and practice but also to allow comparison between cohorts and multi-center analysis of merged data including registries. Efforts to avoid diversification of PIPAC practice include regular update of the PIPAC training curriculum, targeted research and a consensus statement.