Autophagy-mediated regulation of neutrophils and clinical applications. Issue 1 (16th January 2020)

• Record Type: Journal Article
• Authors: Yu, Yao; Sun, Bingwei
• Is Part Of: Burns and trauma. Volume 8:Issue 1(2020)
• Publication Date: 2020-01-16
• Subjects: Autophagy -- Neutrophil -- Innate immunity -- NETs -- Clinical application -- Neutrophil extracellular trap; Burns and scalds -- Periodicals; Wounds and injuries -- Periodicals; 617.11
• DOI: 10.1093/burnst/tkz001
• Languages: English
• ISSNs: 2321-3876

Abstract

Abstract: Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions, including differentiation, degranulation, metabolism and neutrophil extracellular trap formation, that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However, evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here, we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies.