Squamous cell carcinoma of the mandible – Patterns of metastasis and disease recurrence in dependence of localization and therapy. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Moratin, Julius; Horn, Dominik; Metzger, Karl; Ristow, Oliver; Flechtenmacher, Christa; Engel, Michael; Hoffmann, Jürgen; Freier, Kolja; Freudlsperger, Christian
• Is Part Of: Journal of cranio-maxillofacial surgery. Volume 48:Issue 12(2020)
• Page Start: 1158
• Page End: 1163
• Publication Date: 2020-12
• Subjects: OSCC -- Mandible -- Neck dissection -- Metastasis -- Survival; Skull -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Surgery, Plastic -- Periodicals; Maxilla -- surgery -- Periodicals; Face -- surgery -- Periodicals; Skull -- surgery -- Periodicals; Oral Surgical Procedures -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Surgery, Plastic -- Periodicals; Surgery, Oral -- Periodicals; Electronic journals; 617.514
• DOI: 10.1016/j.jcms.2020.10.006
• Languages: English
• ISSNs: 1010-5182

Abstract

Abstract: Introduction: Oral squamous cell carcinomas exhibit distinct patterns of disease progression, depending on their localisation. This study aimed to evaluate clinicopathological data in patients with tumors of the mandibular alveolar process, to facilitate risk assessment and therapy planning. Materials and methods: A retrospective cohort study was designed including patients with squamous cell carcinoma of the mandibular gingiva. Clinical and pathological data were collected to determine the rate of cervical metastases and clinical outcomes depending on tumor stage, localization (anterior, intermediate and posterior) and the extent of tumor resection. Results: 120 patients were included in the analysis. Rate of metastases was 42.6%. Tumors of the anterior part of the mandible exhibited significantly higher rates of bilateral metastases (anterior: 85.7%, intermediate: 15.8%, posterior: 4%, p < 0.001) and local recurrence (anterior: 25%, intermediate: 16.3%, posterior: 5.5%, p = 0.03) compared to posterior malignancies. Conclusion: Tumors of the anterior segment of the mandible are characterized by high rates of metastases and local recurrence. Therefore, we propose radical segmental resection and bilateral neck dissection in those patients.