Sweet as honey, bitter as bile: Mitochondriotoxic peptides and other therapeutic proteins isolated from animal tissues, for dealing with mitochondrial apoptosis. (15th January 2021)

• Record Type: Journal Article
• Authors: Colella, Francesco; Scillitani, Giovanni; Pierri, Ciro Leonardo
• Is Part Of: Toxicology. Volume 447(2021)
• Publication Date: 2021-01-15
• Subjects: MPTP Mitochondria permeability transition pore -- AMP Antimicrobial peptides -- ACE Angiotensin-converting enzyme -- TAT Transactivator of the transcription -- VDAC Voltage-dependent anion-selective channel -- DIDS glutamate and 44′-diisothiocyanatostilbene-22′-disulfonic acid -- PLA2 Phospholipase A2 -- ASGPR Asialoglycoprotein receptor -- CTLA-4 Cytotoxic T-Lymphocyte-associated protein 4 -- ScFv Single-chain variable fragment -- BAX Bcl-2-associated X protein -- pGlu Pyroglutamic acid -- MTT 3-(45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide -- TFPI Tissue factor pathway inhibitor -- FXa Activated factor X -- ER Endoplasmic reticulum -- ROS Reactive oxigen species -- AIF Apoptosis inducing factor -- JNK c-Jun N-terminal kinase -- DMBA 712-dimethylbenz[a]anthracene -- 5-FU 5-Fluorouracil -- PBMC Peripheral blood mononuclear cells -- BNIP3 Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3 -- EAC Ehrlich ascites carcinoma -- 3FTXs Three-finger toxins -- CTX Cardiotoxin -- BAK Bcl-2-Homologous antagonist/killer -- Bcl-2 B-Cell lymphoma 2 -- Bcl-xL B-Cell lymphoma extra-large -- mtDNA Mitochondrial DNA; Mitochondrial-apoptosis -- Mitochondriotoxins -- Mitocans -- Toxin -- Venom -- Poison -- Melittin -- Mastoparan -- Cardiotoxin; Toxicology -- Periodicals; Chemicals -- Physiological effect -- Periodicals; 615.9005
• DOI: 10.1016/j.tox.2020.152612
• Languages: English
• ISSNs: 0300-483X

Abstract

Abstract: Mitochondria are subcellular organelles involved in cell metabolism and cell life-cycle. Their role in apoptosis regulation makes them an interesting target of new drugs for dealing with cancer or rare diseases. Several peptides and proteins isolated from animal and plant sources are known for their therapeutic properties and have been tested on cancer cell-lines and xenograft murine models, highlighting their ability in inducing cell-death by triggering mitochondrial apoptosis. Some of those molecules have been even approved as drugs. Conversely, many other bioactive compounds are still under investigation for their proapoptotic properties. In this review we report about a group of peptides, isolated from animal venoms, with potential therapeutic properties related to their ability in triggering mitochondrial apoptosis. This class of compounds is known with different names, such as mitochondriotoxins or mitocans.