The first line of defense: effector pathways of anti-fungal innate immunity. (December 2020)

• Record Type: Journal Article
• Authors: Ward, Rebecca A; Vyas, Jatin M
• Is Part Of: Current opinion in microbiology. Volume 58(2020)
• Page Start: 160
• Page End: 165
• Publication Date: 2020-12
• Subjects: Microbiology -- Periodicals; 579.05
• DOI: 10.1016/j.mib.2020.10.003
• Languages: English
• ISSNs: 1369-5274

Abstract

Highlights: Fungal recognition by C-type lectin receptors are critical for proper immune response. Innate effector pathways contribute to fungal killing and recruit immune cells. CLR regulation and signaling can be leveraged for novel treatment strategies. Abstract : The innate immune system is critical to proper host defense against fungal pathogens, which is highlighted by increased susceptibility to invasive disease in immunocompromised patients. Innate cells (e.g. macrophages, neutrophils, dendritic cells, eosinophils) are equipped with intricate cell machinery to detect invading fungi and facilitate fungal killing, recruit additional immune cells, and direct the adaptive immune system responses. Understanding the mechanisms that govern a protective response will enable the development of novel treatment strategies. This review focuses on recent insights of signaling and regulation of C-type lectin receptors and their effector mechanisms enabling an effective host antifungal immunity.