Tuberculosis transmission across three states: The story of a solid organ donor born in an endemic country, 2018. Issue 6 (8th July 2020)

• Record Type: Journal Article
• Authors: Jones, Jefferson M.; Vikram, Holenarasipur R.; Lauzardo, Michael; Hill, Amy; Jones, Jeffrey; Haley, Clinton; Seaworth, Barbara; Oldham, Sara; Brown, Marcus; Gutierrez, Felipe; Basavaraju, Sridhar V.
• Is Part Of: Transplant infectious disease. Volume 22:Issue 6(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-08
• Subjects: donor‐derived infections -- solid organ transplantation -- tuberculosis; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13357
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Transmission of tuberculosis (TB) from a deceased solid organ donor to recipients can result in severe morbidity and mortality. In 2018, four solid organ transplant recipients residing in three states but sharing a common organ donor were diagnosed with TB disease. Two recipients were hospitalized and none died. The organ donor was born in a country with a high incidence of TB and experienced 8 weeks of headache and fever prior to death, but was not tested for TB during multiple hospitalizations or prior to organ procurement. TB isolates of two organ recipients and a close contact of the donor had identical TB genotypes and closely related whole‐genome sequencing results. Donors with risk factors for TB, in particular birth or residence in countries with a higher TB incidence, should be carefully evaluated for TB.