A rare case of acute myeloid leukemia with t(12;19)(q13;q13). (2020)

• Record Type: Journal Article
• Authors: Chebly, Alain; Haddad, Fady Gh; Bassil, Josiane; Yammine, Tony; Korban, Rima; Semaan, Warde; El Karak, Fady; Kourie, Hampig Raphael; Farra, Chantal
• Is Part Of: Leukemia research reports. Volume 14(2020)
• Publication Date: 2020
• Subjects: Acute myeloid leukemia -- AML -- M5 -- t(12;19) -- Cytogenetic -- Karyotype; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2020.100216
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.