Palladium‐Catalyzed Oxidative Arylation of 1H‐Indazoles with Arenes. Issue 48 (13th November 2020)

• Record Type: Journal Article
• Authors: Gambouz, Khadija; Abbouchi, Abdelmoula El; Nassiri, Sarah; Suzenet, Franck; Bousmina, Mostapha; Akssira, Mohamed; Guillaumet, Gérald; El Kazzouli, Saïd
• Is Part Of: European journal of organic chemistry. Issue 48(2020)
• Page Start: 7435
• Page End: 7439
• Publication Date: 2020-11-13
• Subjects: C‐H activation -- Homogeneous catalysis -- Nitrogen heterocycles -- Palladium -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202001313
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A simple method for the direct Pd(OAc)2 ‐catalyzed oxidative arylation of inactivated 1 H ‐indazole derivatives with simple arenes is reported. This method exhibits good reaction efficiency and good functional‐group tolerance. Using the developed method, 28 arylated products were prepared in yields up to 80 %. Abstract : Herein we report an efficient Pd(OAc)2 ‐catalyzed oxidative arylation of inactivated 1 H ‐indazole derivatives with simple arenes. The expected C3‐arylation products were obtained in moderate to good yields.