Hydroarylation of N‐Allenyl Derivatives Catalyzed by Copper. Issue 48 (3rd November 2020)

• Record Type: Journal Article
• Authors: Abed Ali Abdine, Racha; Pagès, Lucas; Taillefer, Marc; Monnier, Florian
• Is Part Of: European journal of organic chemistry. Issue 48(2020)
• Page Start: 7466
• Page End: 7469
• Publication Date: 2020-11-03
• Subjects: Allenes -- Copper -- Homogeneous catalysis -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202001333
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : An additive‐free copper catalytic system was used to perform the addition of (hetero)aryl nucleophiles to N ‐allenyl derivatives. This intermolecular C–C bond formation occurs with both complete regio‐ and stereoselectivity to afford the linear ( E ) allylic product with moderate to excellent yields. This atom economical method is the first example of hydroarylation of allenes catalyzed by copper. Abstract : The regio‐ and stereoselective addition of (hetero)aryl nucleophiles to N ‐allenyl derivatives is described under copper catalysis. represents the first example of hydroarylation of allenes catalyzed by copper.