Metal‐Free Selective and Diverse Synthesis of Three Distinct Sets of Isoindolinones from 2‐Alkynylbenzoic Acids and Amines. Issue 47 (17th November 2020)

• Record Type: Journal Article
• Authors: Jia, Xiuwen; Li, Pinyi; Zhang, Xiaoning; Liu, Siyu; Shi, Xingzi; Ma, Wenbo; Dong, Hongbo; Lu, Yangbin; Ni, Hangcheng; Zhao, Fei
• Is Part Of: European journal of organic chemistry. Issue 47(2020)
• Page Start: 7343
• Page End: 7357
• Publication Date: 2020-11-17
• Subjects: Diversity‐oriented synthesis -- Cascade reaction -- Alkynes -- Amines -- Isoindolinone; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202001413
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The metal‐free selective and diverse synthesis of three distinct sets of isoindolinones from 2‐alkynylbenzoic acids and amines has been achieved in a reaction‐condition‐controlled manner. This method exhibits valuable advantageous features such as available starting materials, broad substrate scope, excellent selectivity, good to high yields, good functional group tolerance, simple operation, high bond‐forming efficiency, and step economy, thus providing a convenient and efficient access to a variety of heterocyclic compounds incorporating the bioactive isoindolinone motif. Abstract : The metal‐free selective and diverse synthesis of three distinct sets of isoindolinones from 2‐alkynylbenzoic acids and amines in a controlled manner is reported. This process features metal free, readily available starting materials, broad substrate scope, excellent selectivity, good to high yields, good functional group tolerance, simple operation, high bond‐forming efficiency, and step economy.