Do we understand the pathophysiology of GERD after sleeve gastrectomy?. Issue 1 (6th September 2020)

• Record Type: Journal Article
• Authors: Felinska, Eleni; Billeter, Adrian; Nickel, Felix; Contin, Pietro; Berlth, Felix; Chand, Bipan; Grimminger, Peter; Mikami, Dean; Schoppmann, Sebastian F.; Müller‐Stich, Beat
• Other Names: Giuli Robert guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1482:Issue 1(2020)
• Page Start: 26
• Page End: 35
• Publication Date: 2020-09-06
• Subjects: gastroesophageal reflux -- sleeve gastrectomy -- bariatric surgery -- morbid obesity; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.14467
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Gastroesophageal reflux disease (GERD), a prevalent problem among obese individuals, is strongly associated with obesity and weight loss. Hence, bariatric surgery effectively improves GERD for many patients. Depending on the type of bariatric procedure, however, surgery can also worsen or even cause a new onset of GERD. As a consequence, GERD remains a relevant problem for many bariatric patients, and especially those who have undergone sleeve gastrectomy (SG). Affected patients report not only a decrease in physical functioning but also suffer from mental and emotional problems, resulting in poorer social functioning. The pathomechanism of GERD after SG is most likely multifactorial and triggered by the interaction of anatomical, physiological, and physical factors. Contributing factors include the shape of the sleeve, the extent of injury to the lower esophageal sphincter, and the presence of hiatal hernia. In order to successfully treat post‐sleeve gastrectomy GERD, the cause of the problem must first be identified. Therapeutic approaches include lifestyle changes, medication, interventional treatment, and/or revisional surgery. Abstract : Gastroesophageal reflux disease (GERD) is a prevalent problem among obese individuals. For many of these patients, bariatric surgery effectively improves GERD, but it can also worsen or even cause a new onset of GERD, especially for those who have undergone sleeve gastrectomy (SG). In our narrative review, possible pathomechanisms of GERD after SG are discussed, and available strategies for preventing and treating GERD after SG are elucidated.