Altered gut microbiota in Parkinson's disease patients/healthy spouses and its association with clinical features. (December 2020)

• Record Type: Journal Article
• Authors: Zhang, Fan; Yue, Liya; Fang, Xing; Wang, Gengchao; Li, Cuidan; Sun, Xiaodong; Jia, Xinmiao; Yang, Jingjing; Song, Jinhui; Zhang, Yu; Guo, Chongye; Ma, Guannan; Sang, Ming; Chen, Fei; Wang, Puqing
• Is Part Of: Parkinsonism & related disorders. Volume 81(2020)
• Page Start: 84
• Page End: 88
• Publication Date: 2020-12
• Subjects: Parkinson's disease (PD) -- Gut microbiota dysbiosis -- Clinical features/classifications -- Neurodegenerative disease -- Metagenomics; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2020.10.034
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Introduction: Increasing evidence shows that gut microbiota dysbiosis may play important roles in the occurrence and progression of Parkinson's disease (PD), but the findings are inconsistent. Besides, the effect of family environment on gut microbiota dysbiosis remains unclear. Methods: We characterized the gut microbial compositions of 63 PD patients, 63 healthy spouses (HS) and 74 healthy people (HP) using 16S rRNA sequencing. Clinical phenotypes and microbial composition were analyzed comprehensively. Results: There were markedly different microbial compositions among PD, HS and HP samples by alpha/beta diversity. We also found differential microbial compositions among Hoehn & Yahr stage/disease duration. Eight inflammation-associated microbial genera shared a continuously increase trend with increased Hoehn & Yahr stage and disease duration, indicating characteristic bacteria associated with deterioration in PD. Additionally, seven bacterial markers were identified for accurately differentiating PD patients from the controls (area under the curve [AUC]: 0.856). Conclusions: Our study shows altered gut microbiota in PD patients. Importantly, inflammation-associated microbial genera may play roles in PD progression. Differential microbial compositions in HS and HP samples demonstrate that the gut microbiota are also affected by family environment. Disease-associated metagenomics studies should consider the family environmental factor. Our research provides an important reference and improves the understanding of gut microbiota in PD patients. Highlights: Significantly different microbial compositions between PD and healthy samples; Differential microbial compositions in HS and HP samples; Seven gut bacterial markers for differentiating PD patients from controls; Differential microbial compositions among various PD clinical classifications; Eight inflammation-associated genera may play roles in PD progression.