Rational design of the ratiometric fluorescent probes for sulfur dioxide derivatives and the study on the sensing performance of cyano-containing groups. (February 2021)

• Record Type: Journal Article
• Authors: Peng, Zijian; Shi, Lei; Zeng, Xianqing; Yang, Sheng; Xiao, Jing; Gong, Shengzhao; Xiang, Hua; Shao, Guang
• Is Part Of: Dyes and pigments. Volume 186(2021)
• Publication Date: 2021-02
• Subjects: Ratiometric fluorescent probe -- SO2 derivatives -- Cell imaging -- Michael-addition reaction; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2020.108972
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Sulfur dioxide (SO2 ) and its derivativeshave a close relationship with some physiological processes and many diseases. Herein, a series of fluorescent probes (named as NC1, NC2, and NC3 ) was rationally designed for SO2 derivatives by incorporating various cyano-containing groups to the thienocoumarin moiety. Among them, the probe NC2 with ethyl cyanoacetate moiety could ratiometrically determine SO2 derivatives with ultra-broad emission band gap (211 nm), high selectivity, excellent sensitivity, and fast optical response. More importantly, the cell imaging experiments demonstrated that the probe NC2 could be utilized as a powerful chemical tool for ratiometric visualizing SO2 derivates in biological systems. Graphical abstract: Image 1 Highlights: Three probes with different cyano-containing groups were developed for sensing sulfur dioxide (SO2 ) derivatives. Probe NC2 could detect SO2 derivatives with ultra-broad emission band gap (211 nm) and fast response (160 s). Probe NC2 could be applied to ratiometric determining SO2 derivatives in living cells.