Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Hollin, Thomas; Gupta, Mohit; Lenz, Todd; Le Roch, Karine G.
• Is Part Of: Trends in genetics. Volume 37:Issue 1(2021)
• Page Start: 73
• Page End: 85
• Publication Date: 2021-01
• Subjects: chromatin architecture -- epigenetics -- malaria -- Plasmodium -- transcription factor; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2020.09.003
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract : Multiple hosts and various life cycle stages prompt the human malaria parasite, Plasmodium falciparum, to acquire sophisticated molecular mechanisms to ensure its survival, spread, and transmission to its next host. To face these environmental challenges, increasing evidence suggests that the parasite has developed complex and complementary layers of regulatory mechanisms controlling gene expression. Here, we discuss the recent developments in the discovery of molecular components that contribute to cell replication and differentiation and highlight the major contributions of epigenetics, transcription factors, and nuclear architecture in controlling gene regulation and life cycle progression in Plasmodium spp. Highlights: Nucleosome occupancy and configuration affect gene expression. Epigenetic modifications regulate the parasite genome and the mutually exclusive expression of virulence genes. ApiAP2 are master regulators in the stage transitions. The stereotypical organization of chromosomes in the parasite nucleus facilitates gene expression.