Assessment of the American College of Surgeons surgical risk calculator of outcomes after hepatectomy for liver tumors: Results from a cohort of 950 patients. (December 2020)

• Record Type: Journal Article
• Authors: Donadon, Matteo; Galvanin, Jacopo; Branciforte, Bruno; Palmisano, Angela; Procopio, Fabio; Cimino, Matteo; Del Fabbro, Daniele; Torzilli, Guido
• Is Part Of: International journal of surgery. Volume 84(2020)
• Page Start: 102
• Page End: 108
• Publication Date: 2020-12
• Subjects: Hepatectomy -- Complications -- Mortality -- Liver failure -- Bile leak -- ACS-NSQIP calculator; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; 617.005
• DOI: 10.1016/j.ijsu.2020.10.003
• Languages: English
• ISSNs: 1743-9191

Abstract

Abstract: Background: The American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) calculator has been endorsed to counsel patients regarding complications. The aim of this study was to assess its ability to predict outcomes after hepatectomy. Methods: Outcomes generated by the ACS-NSQIP were recorded in a consecutive cohort of patients. By using established classifications of complications, post-hepatectomy insufficiency and bile leak, the calculator was tested by the comparison of expected versus observed rates of events. The performance of the calculator was tested by using c-statistic and Brier score. Results: 950 patients who underwent hepatectomy between January 2014 and June 2019 were included. Predicted rates were significantly lower than actual rates: the mean ACS-NSQIP morbidity was 17.97% ± 8.4 vs. actual 37.01% ± 0.56 (P < 0.001); the mean ACS-NSQIP mortality was 0.91% ± 1.48 vs. actual 1.76% ± 0.11 (P < 0.001). Predicted length of stay (LOS) was significantly shorter: mean ACS-NSQIP was 5.81 ± 1.66 days vs. actual 10.91 ± 4.6 days (P < 0.001). Post-hepatectomy liver insufficiency and bile leak were recorded in 6.8% and 11.9% of patients, respectively. These events were not expressed by the calculator. C - statistic and Brier scores showed low performance of the calculator. Conclusion: The calculator underestimates the risks of complications, mortality and LOS after hepatectomy. Refinements of the ACS-NSQIP model that account for organ-specific risks should be considered. Highlights: ACS-NSQIP calculator is an important tool to counsel patients and relatives regarding postoperative complications. ACS-NSQIP calculator has not been externally tested in patients undergoing hepatectomy for liver tumors. ACS-NSQIP calculator underestimates the risks of complications, mortality and length of stay after hepatectomy.