Targeting Solute Carrier Transporters through Functional Mapping. (January 2021)

• Record Type: Journal Article
• Authors: Colas, Claire; Laine, Elodie
• Is Part Of: Trends in pharmacological sciences. Volume 42:Number 1(2021)
• Page Start: 3
• Page End: 6
• Publication Date: 2021-01
• Subjects: solute carriers -- protein structure -- protein evolution -- functional mapping; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2020.11.005
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Solute carrier (SLC) transporters are emerging drug targets. Identifying the molecular determinants responsible for their specific and selective transport activities and describing key interactions with their ligands are crucial steps towards the design of potential new drugs. A general functional mapping across more than 400 human SLC transporters would pave the way to the rational and systematic design of molecules modulating cellular transport.