Cytokines in cutaneous lupus erythematosus. (August 2011)

• Record Type: Journal Article
• Authors: Wittmann, Miriam; Goodfield, Mark
• Is Part Of: Expert review of dermatology. Volume 6:Number 4(2011)
• Page Start: 381
• Page End: 394
• Publication Date: 2011-08
• Subjects: cutaneous lupus erythematosus -- damage-associated molecular pattern -- DAMP -- HMGB1 -- IFN-λλ -- IL-18 -- S100 proteins -- TLR -- TNF-αα -- type I interferons; Dermatology -- Periodicals; 616.5005
• DOI: 10.1586/edm.11.39
• Languages: English
• ISSNs: 1746-9872

Abstract

Clinical manifestations of cutaneous lupus erythematosus are diverse and different subtypes of the disease have been defined. It is characteristic for lupus skin inflammation that a significant activation of innate interferon pathways is observable. Endogenous molecules indicative for tissue damage (damage-associated molecular patterns [DAMPs]) show cytokine-like properties once released from intracellular compartments and these DAMPs have been shown to influence the course of inflammatory responses. Cytokines including TNF-αα and IL-1 family members significantly contribute to the chronic inflammatory phenotype and, in combination with DAMPs, impact on the activation of innate interferons. A better understanding of the deregulated cytokine network in cutaneous lupus erythematosus patients with distinct disease phenotypes and genetic backgrounds is of high importance and a prerequisite for recommending and developing more individualized therapeutic strategies.