Adapalene 0.1% and benzoyl peroxide 2.5% combination gel for the treatment of acne vulgaris. (August 2010)

• Record Type: Journal Article
• Authors: Pariser, David
• Is Part Of: Expert review of dermatology. Volume 5:Number 4(2010)
• Page Start: 385
• Page End: 391
• Publication Date: 2010-08
• Subjects: acne -- adapalene -- benzoyl peroxide -- Propionibacterium acnes -- retinoid; Dermatology -- Periodicals; 616.5005
• DOI: 10.1586/edm.10.32
• Languages: English
• ISSNs: 1746-9872

Abstract

Combination therapy is a common approach in the treatment of acne vulgaris to simultaneously target the multiple pathogenic factors. The use of a topical retinoid in conjunction with an antimicrobial agent is a standard-of-care for most cases of acne. Recently, adapalene 0.1% and benzoyl peroxide 2.5% fixed-dose combination gel was approved for the treatment of acne vulgaris. Results from clinical trials provide robust evidence that this fixed-dose combination gel is significantly more efficacious than its corresponding monotherapies and has a mild tolerability profile similar to that of adapalene alone.