A Green Catalyst Fe(OTs)3/SiO2 for theSynthesis of 4‐Pyrrolo‐12‐oxoquinazolines. Issue 46 (10th December 2020)

• Record Type: Journal Article
• Authors: Sai Allaka, Bhargava; Basavoju, Srinivas; Rama Krishna, Gamidi
• Is Part Of: ChemistrySelect. Volume 5:Issue 46(2020)
• Page Start: 14721
• Page End: 14728
• Publication Date: 2020-12-10
• Subjects: 4-Pyrrolo-12-oxoquinazolines -- Fe(OTs)3/SiO2 catalyst -- Green methodology -- Liquid Assisted Grinding (LAG) -- Solvent-free grinding; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202004012
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient and eco‐friendly diversity‐oriented synthetic protocol has been presented to synthesize structurally versatile drug‐like molecules under solvent‐free grinding in the presence of Fe(OTs)3 /SiO2 as a catalyst. The use of Fe(OTs)3 /SiO2 as a recyclable and reusable catalyst has been explored in the synthetic domino protocol involving one‐pot, three component reaction for the synthesis of 4‐pyrrolo‐12‐oxoquinazolines with special features of the protocol like high atom‐economy, operational simplicity, short reaction time and high selectivity with excellent yields. Abstract : We have demonstrated diversity oriented synthetic protocol using Fe(OTs)3 /SiO2, a green and sustainable catalyst. The use of Fe(OTs)3 /SiO2 as a recyclable and reusable catalyst has been explored in the synthetic domino protocol involving one‐pot, three component reaction for the synthesis of 4‐pyrrolo‐12‐oxoquinazolines in grinding method. The special features of this synthetic protocol are high atom economy, operational simplicity, environmentally benign synthesis, short reaction time, high selectivity and excellent yields.