Acute infusion reactions induced by monoclonal antibody therapy. (January 2011)

• Record Type: Journal Article
• Authors: Maggi, Enrico; Vultaggio, Alessandra; Matucci, Andrea
• Is Part Of: Expert review of clinical immunology. Volume 7:Number 1(2011)
• Page Start: 55
• Page End: 63
• Publication Date: 2011-01
• Subjects: anaphylaxis -- anti-TNF-α antibody -- biological agents -- drug allergy -- infliximab -- mAbs -- monoclonal antibodies; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1586/eci.10.90
• Languages: English
• ISSNs: 1744-666X

Abstract

This article reports recent evidence on epidemiological data concerning monoclonal antibody (mAb) infusion-related anaphylaxis, as well as recent data on the correlation between mAb immunogenicity and safety profiles. Pathogenic mechanisms of mAb-related adverse reactions including hypersensitivity, IgE- and non-IgE-mediated events and cytokine release syndrome are also highlighted. Finally, the role of serum anti-mAb antibodies as markers to monitor the safety of such therapeutical compounds are extensively evaluated. The anaphylaxis occurring during therapy with the anti-TNF-α mAb infliximab, largely used in immune-mediated diseases, has been taken as a paradigm