Phenolic compounds from Trigonostemon honbaensis and their cytotoxic activity. Issue 6 (21st December 2020)

• Record Type: Journal Article
• Authors: Ban, Ninh Khac; Truong, Luu Hong; Linh, Tran My; Mai, Nguyen Chi; Yen, Duong Thi Hai; Van Doan, Vu; Nhiem, Nguyen Xuan; Tai, Bui Huu; Van Kiem, Phan
• Is Part Of: Vietnam journal of chemistry. Volume 58:Issue 6(2020)
• Page Start: 759
• Page End: 764
• Publication Date: 2020-12-21
• Subjects: Trigonostemon honbaensis -- phenolic -- cytotoxic activity; Chemistry -- Periodicals; 540
• DOI: 10.1002/vjch.202000068
• Languages: English
• ISSNs: 0866-7144

Abstract

Abstract: Seven phenolic compounds including (±)‐ erythro ‐1‐(3′, 4′, 5′‐trimethoxyphenyl)propane‐1, 2‐diol (1 ), (±)‐ threo ‐1‐(3′, 4′, 5′‐trimethoxyphenyl)propane‐1, 2‐diol (2 ), ( R )‐3‐3‐(3′, 4′‐dimethoxyphenyl)propane‐1, 2‐diol (3 ), (±)‐3‐(3′, 4′, 5′‐trimethoxyphenyl)propane‐1, 2‐diol (4 ), (+)‐syringaresinol (5 ), (7 S, 8 R, 8′ R )‐5, 5′‐dimethoxylariciresinol (6 ), juniperoside (7 ) were isolated from the leaves of Trigonostemon honbaensis . Their chemical structures were determined using ESI‐MS, 1D NMR, and 2D NMR spectra and in comparison with the reported literature. Compounds1 ‐ 7 were reported from Trigonostemon genus for the first time. At concentration of 30 μM, compounds 1 ‐7 exhibited weak cytotoxic activity with cell viability percentages as low as 73.3±0.87 % and 79.5±0.23 % on CAL‐27 and MDA‐MB231 cell lines, respectively.