Cancer Therapy: Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy (Adv. Mater. 50/2020). Issue 50 (15th December 2020)

• Record Type: Journal Article
• Authors: Shao, Dan; Zhang, Fan; Chen, Fangman; Zheng, Xiao; Hu, Hanze; Yang, Chao; Tu, Zhaoxu; Wang, Zheng; Chang, Zhimin; Lu, Junna; Li, Tianyu; Zhang, Yuan; Chen, Li; Leong, Kam W.; Dong, Wen‐fei
• Is Part Of: Advanced materials. Volume 32:Issue 50(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-15
• Subjects: biodegradable mesoporous organosilica nanoparticles -- biomimetic -- chemo‐immunotherapy -- diselenide bonds -- X‐ray radiation responsivity; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202070372
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In article number 2004385, Dan Shao, Kam W. Leong, Wen‐fei Dong, and co‐workers present cancer‐cell‐membrane‐coated mesoporous organosilica nanoparticles for radiation‐responsive drug delivery and cancer chemo‐immunotherapy. Under low‐dose X‐ray radiation, such biomimetic nanotherapeutics exhibit degradation‐controlled drug release and induced stronger antitumor immune responses, leading to enhanced tumor regression and metastasis inhibition with low systematic toxicity when combined with anti‐PD‐L1.