Primary intra‐abdominal melanoma arising in association with extracutaneous blue naevus: a report of two cases. Issue 2 (16th October 2020)

• Record Type: Journal Article
• Authors: Shah, Kabeer; Folpe, Andrew L; Miller, Michael; Morgan, Jeffrey A; Raut, Chandrajit P; Doyle, Leona A
• Is Part Of: Histopathology. Volume 78:Issue 2(2021)
• Page Start: 281
• Page End: 289
• Publication Date: 2020-10-16
• Subjects: blue naevus -- immunohistochemistry -- melanoma -- molecular genetics -- sarcoma; Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.14219
• Languages: English
• ISSNs: 0309-0167

Abstract

Abstract : Aims: Blue naevi are uncommon dermal melanocytic neoplasms characterised by GNAQ / GNA11 mutations, which very rarely progress to melanoma. Such melanomas also often have BAP1 mutations, and lack genetic events associated with conventional melanoma. Exceptionally, blue naevi arise in extracutaneous locations; one melanoma arising in this setting has been reported. We report the clinicopathological, immunohistochemical and molecular genetic features of two cases of melanoma arising in extracutaneous blue naevus. Methods and results: Both arose in males, aged 25 and 63 years, with no history of other melanocytic lesions, and presented as large, painful intra‐abdominal masses. The tumours were dark‐brown/black, multilobulated, involved small intestinal mesentery and consisted of a predominantly fascicular and spindled, but occasionally nested and epithelioid, proliferation of variably pigmented, relatively monotonous cells with pale cytoplasm and ovoid nuclei with mild to moderate atypia. Mitotic activity was variable but generally low. Both cases showed areas of conventional and cellular blue naevus. Recurrent tumour in one case showed predominantly epithelioid morphology and greater cytological atypia and mitotic activity. One case expressed Melan‐A, SOX10 and CD117, with absent expression of S100 protein and DOG1; the other expressed Melan‐A, HMB45 and S100 protein. Next‐generation sequencing identified GNAQ and BAP1 mutations in one case and GNA11 mutation in the other. Both patients developed widespread metastatic disease. Conclusion: Exceptionally rare, aggressive melanomas arising in extracutaneous blue naevi should be distinguished from metastatic melanoma, gastrointestinal stromal tumour and malignant melanotic nerve sheath tumour, especially given the significant therapeutic and prognostic differences between these different entities.