Fatigue in inflammatory bowel disease and its impact on daily activities. Issue 1 (7th November 2020)

• Record Type: Journal Article
• Authors: Schreiner, Philipp; Rossel, Jean‐Benoît; Biedermann, Luc; Valko, Philipp O.; Baumann, Christian R.; Greuter, Thomas; Scharl, Michael; Vavricka, Stephan R.; Pittet, Valérie; Juillerat, Pascal; Rogler, Gerhard; von Känel, Roland; Misselwitz, Benjamin
• Other Names: Abdelrahman Karim investigator.; Ademi Gentiana investigator.; Aepli Patrick investigator.; Thomas Amman investigator.; Anderegg Claudia investigator.; Antonino Anca‐Teodora investigator.; Archanioti Eva investigator.; Arrigoni Eviano investigator.; Aslan Nurullah investigator.; Bakker de Jong Diana investigator.; Balsiger Bruno investigator.; Bastürk Polat investigator.; Bauerfeind Peter investigator.; Becocci Andrea investigator.; Bengoa José M investigator.; Biedermann Luc investigator.; Binek Janek investigator.; Blattmann Mirjam investigator.; Boehm Stephan investigator.; Boldanova Tujana investigator.; Borovicka Jan investigator.; Braegger Christian P investigator.; Brand Stephan investigator.; Bravo Francisco investigator.; Brügger Lukas investigator.; Brunner Simon investigator.; Bühr Patrick investigator.; Burk Sabine investigator.; Burri Emanuel investigator.; Butter Matthias investigator.; Buyse Sophie investigator.; Cao Dahlia‐Thao investigator.; Carstens Ove investigator.; Criblez Dominique H investigator.; D'Angelo Fabrizia investigator.; Saussure Philippe investigator.; Degen Lukas investigator.; Delarive Joakim investigator.; Doerig Christopher investigator.; Dora Barbara investigator.; Drerup Susan investigator.; Ducrey Carole investigator.; El‐Wafa Ali investigator.; Engelmann Matthias investigator.; Erdmann‐Voisin Aude investigator.; Felley Christian investigator.; Fliegner Markus investigator.; Fraga Montserrat investigator.; Franc Yannick investigator.; Frei Pascal investigator.; Frei Remus investigator.; Fried Michael investigator.; Froehlich Florian investigator.; Furlano Raoul Ivano investigator.; Garzoni Luca investigator.; Geyer Martin investigator.; Girardin Marc investigator.; Golay Delphine investigator.; Good Ignaz investigator.; Bigler Ulrike Graf investigator.; Godat Sébastien investigator.; Greuter Thomas investigator.; Gysi Beat investigator.; Haarer Johannes investigator.; Halama Marcel investigator.; Haldemann Janine investigator.; Heer Pius investigator.; Heimgartner Benjamin investigator.; Helbling Beat investigator.; Hengstler Peter investigator.; Herzog Denise investigator.; Hess Cyrill investigator.; Hessler Roxane investigator.; Heyland Klaas investigator.; Hinterleitner Thomas investigator.; Hirschi Claudia investigator.; Hruz Petr investigator.; Juillerat Pascal investigator.; Kapoglou Ioannis investigator.; Kayser Stephan investigator.; Keller Céline investigator.; Khalid‐de Bakker Carolina investigator.; Knellwolf Christina investigator.; Knoblauch Christoph investigator.; Köhler Henrik investigator.; Koller Rebekka investigator.; Krieger Claudia investigator.; Künzler Patrizia investigator.; Kusche Rachel investigator.; Lehmann Frank Serge investigator.; Macpherson Andrew investigator.; Maillard Michel H investigator.; Manz Michael investigator.; Martinho Maude investigator.; Meier Rémy investigator.; Meyenberger Christa investigator.; Meyer Pamela investigator.; Michetti Pierre investigator.; Misselwitz Benjamin investigator.; Morell Bernhard investigator.; Mosler Patrick investigator.; Moschouri Eleni investigator.; Mottet Christian investigator.; Müller Christoph investigator.; Müllhaupt Beat investigator.; Musso Leilla investigator.; Neagu Michaela investigator.; Nichita Cristina investigator.; Niess Jan investigator.; Nydegger Andreas investigator.; Obialo Nicole investigator.; Oropesa Cassandra investigator.; Peter Ulrich investigator.; Peternac Daniel investigator.; Petit Laetitia Marie investigator.; Pittet Valérie investigator.; Pohl Daniel investigator.; Porzner Marc investigator.; Preissler Claudia investigator.; Raschle Nadia investigator.; Rentsch Ronald investigator.; Restellini Sophie investigator.; Richterich Jean‐Pierre investigator.; Riedmüller Sandra investigator.; Risti Branislav investigator.; Ritz Marc Alain investigator.; Rogler Gerhard investigator.; Röhrich Nina investigator.; Rossel Jean‐Benoît investigator.; Roth René investigator.; Rueger Vanessa investigator.; Sagmeister Markus investigator.; Saner Gaby investigator.; Sarraj Riad investigator.; Sauter Bernhard investigator.; Sawatzki Mikael investigator.; Scharl Michael investigator.; Scharl Sylvie investigator.; Schelling Martin investigator.; Schibli Susanne investigator.; Schlauri Hugo investigator.; Schluckebier Dominique investigator.; Schmid Daniela investigator.; Schmid Sybille investigator.; Schnegg Jean‐François investigator.; Schoepfer Alain investigator.; Schreiner Philipp investigator.; Seibold Frank investigator.; Seirafi Mariam investigator.; Semadeni Gian‐Marco investigator.; Senning Arne investigator.; Sokollik Christiane investigator.; Sommer Joachim investigator.; Spalinger Johannes investigator.; Spangenberger Holger investigator.; Stadler Philippe investigator.; Staub Peter investigator.; Staudenmann Dominic investigator.; Stenz Volker investigator.; Steuerwald Michael investigator.; Straumann Alex investigator.; Stulz Andreas investigator.; Sulz Michael investigator.; Tempia‐Caliera Michela investigator.; Thorens Joël investigator.; Truninger Kaspar investigator.; Tutuian Radu investigator.; Urfer Patrick investigator.; Vavricka Stephan investigator.; Viani Francesco investigator.; Vinzens Fabrizion investigator.; Vögtlin Jürg investigator.; Von Känel Roland investigator.; Vouillamoz Dominique investigator.; Vulliamy Rachel investigator.; Vullièmoz Marianne investigator.; Wiesel Paul investigator.; Wiest Reiner investigator.; Wöhrle Stefanie investigator.; Yilmaz Bahtiyar investigator.; Zamora Samuel investigator.; Zander Silvan investigator.; Zeitz Jonas investigator.; Zimmermann Dorothee investigator.;
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 53:Issue 1(2021)
• Page Start: 138
• Page End: 149
• Publication Date: 2020-11-07
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.16145
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Fatigue is a common symptom of chronic inflammation, including inflammatory bowel disease (IBD), resulting in significant impairment in quality of life. Aims: To identify the prevalence of fatigue in a large IBD cohort compared to the general population, address risk factors, and evaluate its impact on daily life. Methods: We evaluated 1208 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) and 414 healthy controls. Significant fatigue was defined as a visual analogue scale (VAS‐F, range 0‐10) score ≥ 4. Secondary endpoints were severity of fatigue and its impact on daily activities with the Fatigue Severity Scale (FSS), with a score ≥ 4 indicative of fatigue. Demographic, IBD‐related and psychiatric symptoms were assessed with a multivariate analysis of variance (MANOVA) model optimised for prediction of VAS‐F (primary outcome) and FSS scores. Results: Overall, 672 IBD patients (55.6%) reported significant fatigue compared to 145 (35%) controls (OR 2.71; 95% CI 2.08‐3.54; P < 0.001). In IBD, fatigue also significantly affected daily activities (FSS ≥ 4; 405 (33.5%) IBD patients vs 81 (19.6%) controls, P < 0.001). In the MANOVA model, fatigue levels were associated with female gender (coefficient 0.839; 0.556 ‐ 1.123; P < 0.001), younger age at diagnosis (−0.031 per year; −0.042– −0.019; P < 0.001), shorter disease duration (−0.036 per year; −0.050– −0.022; P < 0.001), nocturnal diarrhoea (0.718; 0.295‐1.141; P = 0.001), low educational level ( P = 0.034) and symptoms of depression and anxiety. Conclusions: Fatigue is both more frequent and more severe in patients with IBD than in the general population.