Local excision versus radical resection in patients with rectal neuroendocrine tumours: a propensity score match analysis. Issue 12 (17th August 2020)

• Record Type: Journal Article
• Authors: Zhao, Beiqun; Hollandsworth, Hannah M.; Lopez, Nicole E.; Parry, Lisa A.; Abbadessa, Benjamin; Cosman, Bard C.; Ramamoorthy, Sonia L.; Eisenstein, Samuel
• Is Part Of: ANZ journal of surgery. Volume 90:Issue 12(2020)
• Page Start: E154
• Page End: E162
• Publication Date: 2020-08-17
• Subjects: carcinoid -- National Cancer Database -- propensity score matching -- rectal neuroendocrine tumour; Surgery -- Periodicals; 617.005
• DOI: 10.1111/ans.16221
• Languages: English
• ISSNs: 1445-1433

Abstract

Abstract: Background: The rectum is a common site for neuroendocrine tumours of the gastrointestinal tract. Diagnosis of these tumours has been increasing in recent years, highlighting the need to better define treatment options for patients with rectal neuroendocrine tumours (rNETs). Methods: We performed a retrospective analysis using the National Cancer Database (2004–2014) to compare overall survival (OS) between local excision (LE) and radical resection (RR). To minimize bias, we performed three propensity score‐matched comparisons stratified by tumour size: <10 mm, 10–20 mm, >20 mm. We compared OS by Kaplan–Meier analysis. We also examined margin status and postoperative outcomes for each comparison. Results: A total of 12 996 patients underwent surgical treatment for rNET. There was no significant difference in probability of 10‐year OS between LE and RR for patients with tumours <10 mm (88.6% versus 83.8%, P = 0.631, respectively) and tumours 10‐20 mm (69.5% versus 69.3%, P = 0.226, respectively). In patients with tumours >20 mm, probability of 10‐year OS was significantly longer in the LE group (76.5% versus 37.0%, P < 0.001). For all tumour sizes <10 mm and >20 mm, RR had significantly higher rates of 30‐day readmission and negative margins. In subset analysis, there was no difference in OS for patients with positive margins after LE versus negative margins after RR for all tumour size groups. Conclusions: Our findings suggest that LE is a reasonable treatment option in patients with rNETs, especially for patients with high perioperative risk. Limitations to this study include its retrospective nature and inability to analyse surgeon decision‐making. Abstract : In our propensity score match analysis of patients with rectal neuroendocrine tumours, we show that radical resection may not be associated with improved overall survival and that local excision is a reasonable treatment option for patients.