Front Cover: Evaluation of 5H‐Thiazolo[3, 2‐α]pyrimidin‐5‐ones as Potential GluN2A PET Tracers (ChemMedChem 24/2020). (26th November 2020)

• Record Type: Journal Article
• Authors: He, Yingfang; Whitehead, David M.; Briard, Emmanuelle; Numao, Shin; Mu, Linjing; Schibli, Roger; Ametamey, Simon M.; Auberson, Yves P.
• Is Part Of: ChemMedChem. Volume 15:Number 24(2020)
• Page Start: 2332
• Page End: 2332
• Publication Date: 2020-11-26
• Subjects: receptor -- imaging agent -- radiochemistry -- NMDA -- defluorination; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202000909
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Front Cover shows the postsynaptic location of GluN2A‐containing NMDA receptors, their ligand‐binding domain, as well as a close‐up of [ 18 F]7b bound to the receptor with the corresponding images obtained by in vitro autoradiography of rat brain sections in a blocking study. Both [ 18 F]7b and its tritiated analogue [ 3 H2 ]15b are valuable new tools for the study of GluN2A‐containing NMDA receptors, and for the optimization of allosteric modulators binding to the dimer interface of the GluN1‐GluN2A ligand‐binding domain. More information can be found in the Full Paper by Simon M. Ametamey, Yves P. Auberson et al.