Correlation analysis between advanced glycation end products detected noninvasively and skin aging factors. (13th May 2020) - Xin, Cong
Abstract: Objective: To investigate the correlation between advanced glycation end products (AGEs) and skin elasticity or blood perfusion values in healthy people of different age groups and to evaluate the relationship between noninvasive detection of AGEs and age or skin aging. Methods: One hundred and two healthy people were enrolled and grouped into groups of 20 years old. Group I: 19‐40 years old; Group II: 41‐60 years old; Group III: 61‐80 years old. Noninvasive techniques such as fluorescence spectroscopy and laser speckle flowmetry were used to detect AGEs levels, local skin perfusion value, and skin elasticity in skin tissue at all age groups. Result: The AGEs in the skin increased with age, and the difference between the three age groups was statistically significant ( P < .05).There was no significant difference in gender between AGEs ( P > .05).There was no significant relationship between AGEs and skin elasticity or blood perfusion value in the Group I; there was a low correlation between AGEs and skin elasticity in the 41‐60 years age group ( r < .4, P < .05). The level of AGEs in the elderly over 60 years was significantly positively correlated with skin elasticity and blooding perfusion value ( r > .4, P < .05). Conclusion: There is a significant correlation between AGEs and age or skin aging indicators. As the age increasing, the level of AGEs increases obviously, which can be used as a potential noninvasive tool for detecting skin aging.