Palladium‐Catalyzed Distal C−H Selenylation of 2‐Aryl Acetamides with Diselenides and Selenyl Chlorides. Issue 24 (9th November 2020)

• Record Type: Journal Article
• Authors: He, Meicui; Gu, Linghui; Tan, Yuqiang; Wang, Yang; Wang, Yuchi; Zhang, Chunran; Ma, Wenbo
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 24(2020)
• Page Start: 5708
• Page End: 5715
• Publication Date: 2020-11-09
• Subjects: Palladium catalyst -- C−H selenylation -- Removable directing group -- 2-Aryl acetamides -- Single-electron transfer; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000948
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A convenient and effective method of palladium‐catalyzed C−H selenylation of the 2‐aryl acetamides assisted with removable 8‐aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene‐pinone. Preliminary mechanistic studies indicated that a single‐electron transfer type mechanism and facile C−H metalation are operative. Abstract :