C-type natriuretic-derived peptides as biomarkers in human disease. (August 2010)

• Record Type: Journal Article
• Authors: Lippert, Solvej; Goetze, Jens Peter
• Is Part Of: Biomarkers in medicine. Volume 4:Number 4(2010)
• Page Start: 631
• Page End: 639
• Publication Date: 2010-08
• Subjects: ANP -- atrial natriuretic peptide -- biomarker -- BNP -- B-type natriuretic peptide -- CNP -- C-type natriuretic peptide natriuretic peptide -- proCNP -- radioimmunoassay; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.10.67
• Languages: English
• ISSNs: 1752-0363

Abstract

The natriuretic peptide system comprises three structurally related peptides: atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide. In circulation, they play an important endocrine role in the regulation of cardiovascular homeostasis by maintaining blood pressure and extracellular fluid volume. Atrial natriuretic peptide and B-type natriuretic peptide have gained considerable diagnostic interest as biomarkers in cardiovascular disease. By contrast, C-type natriuretic peptide has not yet been ascribed a role in human diagnostics. This perspective aims at recapitulating the present biochemical and clinical issues concerning C-type natriuretic peptide measurement in plasma as a potential biomarker.